[Diffusion of ceftriaxone in human bone tissue].

Ceftriaxone diffusion into spongious and cortical bone after single 2 g dose by intravenous injection was studied in 40 patients undergoing total hip replacement. Serum and tissue assays were performed by HPLC and microbiological method 2, 4, 12 and 24 hours after administration. Both methods produced similar results.