Surface modification of AISI 316L stainless steel by applying single and multilayer coatings: Study of elastic modulus and antibacterial properties.

AISI 316L stainless steel is extensively used in various fields, including medicine. In this study, in order to improve antibacterial properties, reduce elastic modulus, increase hydrophilicity and delay corrosion on the surface of AISI 316L stainless steel pieces for biomedical applications, zinc and magnesium elements were used for coating. Zn monolayer, Zn-Mg bilayer, and Zn-Mg-Zn triple coatings were deposited on AISI 316L substrates using the thermal evaporation method.

Surface Enhancement of Titanium Ti-3Al-2.5V Through Laser Remelting Process-A Material Analysis.

This study evaluates the effects of laser parameters on the surface remelting of the Ti-3Al-2.5V alloy. A ms-laser equipped with a coaxial gas-pressure head integrated into a Swiss-type turning machine is used for the laser remelting process of cylindrical parts.

Multimodal tumor suppression by METTL3 gene knockdown in melanoma and colon cancer cells.

METTL3, an m6A methyltransferase, is integral to the regulation of messenger RNA (mRNA) biogenesis, degradation, and translation through the N6-methyladenosine (m6A) modification. Alterations in m6A homeostasis have been implicated in the development, progression, invasion, and metastasis of certain cancers. The present research aims to examine the consequences of METTL3 knockdown using short hairpin RNA (shRNA) on the proliferation and invasive capabilities of human colorectal and melanoma cancer cell lines.

Phosphatidic acid as a cofactor of mTORC1 in platinum-based chemoresistance: Mechanisms and therapeutic potential.

Platinum-based chemotherapeutics, such as cisplatin and carboplatin, are widely used to treat various malignancies. However, the development of chemoresistance remains a significant challenge, limiting their efficacy. This review explores the multifaceted mechanisms of platinum-based chemoresistance, with a particular focus on the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which plays a critical role in promoting tumor survival and resistance to platinum compounds.

LncRNA DANCR-V1 is a novel regulator of Wnt/β-catenin and TGF-β1/SMAD signaling pathways in colorectal cancer: an in vitro and in silico study.

Background: DANCR is an oncogenic lncRNA associated with advanced colorectal cancer, one of the most common malignancies worldwide. This lncRNA has a new variant, DANCR-V1, whose function is not yet understood. In this study, we aimed to evaluate the expression pattern of DANCR-V1 and its regulatory mechanism in colorectal cancer.