Synthesis of Ag nanoparticles by a chitosan-poly(3-hydroxybutyrate) polymer conjugate and their superb catalytic activity.

This work describes an eco-friendly and sustainable technique for the synthesis of silver nanoparticles (nAg), where chitosan-poly(3-hydroxybutyrate) polymer conjugate (Chit-PHB) acts as a reducing and stabilizing material. The ensuing nanoparticles show an exceptional catalytic activity in the reduction of 4-nitrophenol to 4-aminophenol. nAg were characterized by several techniques, i.

The Use of a Biopolymer Conjugate for an Eco-Friendly One-Pot Synthesis of Palladium-Platinum Alloys.

Raising health and environmental concerns over the nanoparticles synthesized from hazardous chemicals have urged researchers to focus on safer, environmentally friendlier and cheaper alternatives as well as prompted the development of green synthesis. Apart from many advantages, green synthesis is often not selective enough (among other issues) to create shape-specific nanoparticle structures. Herein, we have used a biopolymer conjugate and Pd and Pt precursors to prepare sustainable bimetallic nanoparticles with various morphology types.

Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α.

Our group has recently reported that in the immortal human HepG2 liver cell line, sphingosine 1‑phosphate (S1P) increases transcription of plasminogen activator inhibitor type‑1 (PAI‑1), the major physiological inhibitor of fibrinolysis, within 4 h. The present study aimed to elucidate the molecular mechanisms underlying this effect. PAI‑1 expression was measured by reverse transcription‑quantitative polymerase chain reaction and immunoblotting.

Human epicardial cell-conditioned medium contains HGF/IgG complexes that phosphorylate RYK and protect against vascular injury.

Aims: The aim of this study was to evaluate the paracrine activity of human epicardial-derived cells (hEPDCs) to screen for secreted vasoprotective factors and develop therapeutics to treat vascular reperfusion injury.

Methods And Results: Epicardial cells support cardiac development, repair, and remodelling after injury in part, through paracrine activity. We hypothesized that secreted ligands from hEPDCs would protect vascular integrity after myocardial infarction (MI) with reperfusion.

Differential effects of insulin sensitization and insulin provision treatment strategies on concentrations of circulating adipokines in patients with diabetes and coronary artery disease in the BARI 2D trial.

Aims: To determine the effects of insulin sensitization (IS) and insulin provision (IP) treatment strategies on adipokines associated with cardiovascular disease in patients with type 2 diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial (BARI 2D).

Methods And Results: Changes in adipokine levels were compared in patients with type 2 diabetes mellitus and coronary artery disease randomized to IS (n = 1037) versus IP (n = 1019) treatment strategies in BARI 2D. Circulating concentrations of leptin, adiponectin, monocyte chemoattractant protein-1, tumor necrosis factor-alpha, interleukin 6 and C-reactive protein were evaluated at baseline and one year.