Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation.

Objective: There is renewed interest in targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) for treatment of obesity and type 2 diabetes. G-protein coupled receptor desensitisation is suggested to reduce the long-term efficacy of glucagon-like-peptide 1 receptor (GLP-1R) agonists and may similarly affect the efficacy of GIPR agonists. We explored the extent of pancreatic GIPR functional desensitisation with sustained agonist exposure.

Innovations in Dementia Empowerment and Action [IDEA]: First Dementia/Memory Loss RCT Intervention for Sexual and Gender Minority Older Adults and Their Care Partners.

Background: Sexual and gender minority (SGM) older adults experience disparities in subjective cognitive impairment when compared to heterosexuals of similar age. Yet, SGM older adults and their care partners living with dementia/memory loss face substantial barriers to accessing culturally relevant health and dementia care. To address the gap in culturally relevant interventions, we tested the efficacy of a first of its kind stigma reduction, cognitive behavioral intervention for SGM older adults living with dementia/memory loss and their care partners, Aging with Pride: Innovations in Empowerment and Action (IDEA).

Autoregulation of the glial gene reversed polarity in Drosophila.

During development, cells of the nervous system begin as unspecified precursors and proceed along one of two developmental paths to become either neurons or glia. Work in the fruit fly Drosophila melanogaster has established the role of the transcription factor Glial cells missing (Gcm) in directing neuronal precursor cells to assume a glial cell fate. Gcm acts on many target genes, one of which is reversed polarity (repo).

Comparison of Mean Values and Entropy in Accelerometry Time Series from Two Microtechnology Sensors Recorded at 100 vs. 1000 Hz During Cumulative Tackles in Young Elite Rugby League Players.

Several microtechnology devices quantify the external load of team sports using Global Positioning Systems sampling at 5, 10, or 15 Hz. However, for short, explosive actions, such as collisions, these sample rates may be limiting. It is known that very high-frequency sampling is capable of capturing changes in actions over a short period of time.

Impact of Removing the Monitoring Requirements for Holdings with Atypical Scrapie in Great Britain.

Atypical scrapie (AS) is a transmissible spongiform encephalopathy (TSE) that affects sheep and goats. Low within-flock incidence suggests that AS is not transmissible between animals, and testing of all animals that exit positive flocks for two years following detection (i.e.