Publications by authors named "B Siva Sai"

The analysis of connection strengths and distances in the mobility network is pivotal for delineating critical pathways, particularly in the context of epidemic propagation. Local connections that link proximate districts typically exhibit strong weights. However, ties that bridge distant regions with high levels of interaction intensity, termed strong long (SL) ties, warrant increased scrutiny due to their potential to foster satellite epidemic clusters and extend the duration of pandemics.

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  • MAZ is found to have increased expression in melanoma, which is linked to worse prognosis for patients.
  • MAZ contributes to melanoma’s aggressive behavior by promoting cell growth, movement, and invasion.
  • The study identifies MAZ's role in regulating NDUFS3, a key mitochondrial protein, suggesting that the levels of MAZ and NDUFS3 together could be used as a predictive marker for melanoma prognosis.
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Complementary resource use by functionally different species may accelerate ecosystem processes. However, how co-variation in plant traits and animal traits promotes complementarity through temporal plant-animal interactions is poorly understood, even less so in detrital systems, thereby hampering our fundamental understanding of decomposition and carbon turnover. We hypothesised that, in seasonal subtropical forests where termites are major deadwood decomposers, trait complementarity of both termite species and tree species should promote overall deadwood decomposition through different seasons and years.

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Renal cell carcinoma (RCC) is distinguished by its varied metabolic reprogramming driven by tumor suppressor gene dysregulation and oncogene activation. Tumors can adapt nutrient uptake and metabolism pathways to meet the altered biosynthetic, bioenergetic and redox demands of cancer cells, whereas conventional chemotherapeutics and molecular inhibitors predominantly target individual metabolic pathways without addressing this adaptability. Flavonoids, which are well‑known for their antioxidant and anti‑inflammatory properties, offer a unique approach by influencing multiple metabolic targets.

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  • - NOD2 is an important immune sensor that has a tumor-suppressive effect in melanoma by inhibiting cell proliferation, migration, and invasion while promoting apoptosis.
  • - The study found that NOD2 regulates thymidylate synthase (TYMS) expression through a specific ubiquitination process, which makes melanoma cells more sensitive to chemotherapeutic drugs like 5-fluorouracil (5-FU) and capecitabine (CAP).
  • - Additionally, the research indicates that combining a PLK1 inhibitor (volasertib) with these chemotherapy drugs can work synergistically to further enhance the suppression of melanoma cell growth and migration.
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