Publications by authors named "B Singa"
Article Synopsis
- HEU (HIV-exposed uninfected) children face a higher risk of hospitalization and mortality compared to HUU (HIV-unexposed uninfected) children, prompting a closer look at their health outcomes.
- A study of 1486 children revealed that HEU children had significantly higher rates of hospitalization mortality and were more prone to wasting and stunting.
- Despite similar illness severity and resource use in hospitals, HEU children had longer stays and a two-fold increased risk of dying within 30 days of hospitalization compared to HUU peers.
In sub-Saharan Africa, children with severe malnutrition (SM) and HIV have substantially worse outcomes than children with SM alone, facing higher mortality risk and impaired nutritional recovery post-hospitalisation. Biological mechanisms underpinning this risk remain incompletely understood. This case-control study nested within the CHAIN cohort in Kenya, Uganda, Malawi, and Burkina Faso examined effect of HIV on six months post-discharge growth among children with SM and those at risk of malnutrition, assessed proteomic signatures associated with HIV in these children, and investigated how these systemic processes impact post-discharge growth in children with SM.
View Article and Find Full Text PDFBackground: Malnutrition and HIV interact in a vicious cycle for HIV-exposed infants (HEIs), increasing vulnerability and the severity of each condition and contributing to poor health outcomes. We identified multi-level factors influencing provider adherence to Kenyan HIV and nutrition guidelines for HEIs.
Methods: We conducted six focus group discussions and seven in-depth interviews using a semi-structured question guide.
Introduction: We used machine learning to identify novel strategies to target azithromycin to the children with watery diarrhea who are most likely to benefit.
Methods: Using data from a randomized trial of azithromycin for watery diarrhea, we developed personalized treatment rules given sets of diagnostic, child, and clinical characteristics, employing a robust ensemble machine learning-based procedure. For each rule, we estimated the proportion treated under the rule and the average benefits of treatment.
Characteristics and outcomes of children 2-23 months of age with prolonged diarrhoea: A secondary analysis of data from the 'Antibiotics for Children with Diarrhea' trial.
J Glob Health
October 2024
Article Synopsis
- About 12% of diarrhoeal cases last 7-13 days, termed prolonged diarrhoea, which is linked to the majority of diarrhoeal deaths in young children.
- The study evaluated young children (2-23 months) with acute (<7 days) and prolonged (≥7-13 days) diarrhoea using data from a large trial conducted across seven countries in Asia and sub-Saharan Africa between 2017 and 2019.
- Findings showed that prolonged diarrhoea was associated with factors like younger age, larger family size, maternal illiteracy, moderate underweight, and the presence of certain pathogens, with significant implications for children's health outcomes at a 90-day follow-up.