replaces virulence with carbapenem resistance via porin loss.

Pathogenic species are of increasing clinical concern due to the multidrug-resistant nature of these bacteria, including resistance to carbapenem antibiotics. Our understanding of virulence is limited, hindering the development of new prophylactics and therapeutics targeting infections caused by species. In this study, we assessed the virulence of contemporary clinical isolates in a mouse model of intraperitoneal infection and used comparative genomics to identify genes promoting virulence.

Does PCR-based pathogen identification reduce mortality in bloodstream infections? Insights from a difference-in-difference analysis.

Background: Bloodstream infections (BSI) are associated with high mortality rates, particularly when caused by resistant pathogens. Reducing the delay in diagnosis and initiation of appropriate treatment is crucial for improving clinical outcomes. The implementation of polymerase chain reaction (PCR) tests in the diagnostic process offers a promising approach to achieving quicker identification of pathogens, thereby potentially reducing mortality associated with BSI.

Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent.

Gastrointestinal (GI) colonization by methicillin-resistant (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune and microbial factors that permit GI colonization remain unknown. Male sex is correlated with enhanced nasal carriage, skin and soft tissue infections, and bacterial sepsis.

Collagen binding adhesin restricts skin infection.

causes approximately 80% of skin and soft tissue infections (SSTIs). Collagen is the most abundant human extracellular matrix protein with critical roles in wound healing, and encodes a collagen binding adhesin (Cna). The role of this protein during skin infections is unknown.