Effects of dietary alteration on trimethylaminuria as measured by mass spectrometry.

The urine of a 9-year-old boy suffering from extreme body odour was assayed for trimethylamine (TMA) by gas chromatography-mass spectrometry. A trapping column bed, specifically designed for volatile compounds, was used in the mass spectrometry. The diagnosis of rare trimethylaminuria was confirmed by the presence of appreciable urinary TMA.

Exaggerated somatomedin-C response to human growth hormone infusion in patients with type II diabetes mellitus.

The suggestion of a role for the abnormally regulated growth hormone (GH) in the pathogenesis of diabetes mellitus (DM), implicates also the somatomedins, as mediators of some of GH actions. The present study was aimed at assessing the somatomedin response to exogenous GH administration in diabetes type II (NIDDM) subjects as well as its possible relationship with the degree of control of diabetes. Twenty-two subjects (seven controls and 15 NIDDM patients), matched for sex and age, underwent human GH infusion (0.

Lack of von Willebrand factor, factor VIII related antigen and factor VIII coagulant response to human growth hormone infusion in type 2 diabetes mellitus.

Excessive growth hormone (GH) secretion and platelet hyperaggregation have been considered to be involved in the development of the vascular complications of diabetes mellitus (DM). Trying to find a common link between GH and platelet hyperaggregation, we measured von Willebrand or ristocetin cofactor activity (VIII R:Rcof), factor VIII-related antigen (VIII R:Ag) and factor VIII coagulant activity (VIII:C) in ten type 2 DM (NIDDM) and seven normal control (C) human subjects. These three parameters were measured before (time 0), and after a one-hour intravenous infusion of 0.

Increased [125I]trypsin-binding in serum from cystic fibrosis patients.

The capacities of normal and cystic fibrosis (CF) sera to bind to exogenous human [125I]trypsin were compared. Sera from eight older CF patients bound significantly more exogenous human [125I]trypsin than did sera from eight normal subjects (p less than 0.001).