Publications by authors named "B Shamsian"
Introduction: Acute kidney injury (AKI) is a frequent complication after hematopoietic stem cell transplantation (HSCT), with reported incidences ranging from 20-70% within the first 100 days post-transplant. AKI can adversely impact outcomes and survival in this patient population.
Methods: This retrospective study evaluated 110 pediatric patients who underwent HSCT at Mofid Children's Hospital, affiliated with Shahid Beheshti University of Medical Sciences, Tehran, Iran, between 2016-2021.
Article Synopsis
- Chemotherapy-induced mucositis is a common and painful side effect in cancer treatment, necessitating effective solutions to alleviate its severity and duration.
- This study investigated the effectiveness of Mucosamin spray as an additional preventive measure against oral mucositis in pediatric patients undergoing chemotherapy.
- Results showed no significant difference in the incidence or severity of mucositis between the groups, but the intervention group experienced a significantly shorter healing time.
Background: Elevated level of double-negative T (DNT) cells is a historical hallmark of autoimmune lymphoproliferative syndrome (ALPS) diagnosis. However, the peripheral blood level of DNT cells might also be compromised in autoimmune lymphoproliferative immunodeficiencies (ALPID) other than ALPS, inattention to which would increase the delay in diagnosis of the underlying genetic defect and hinder disease-specific treatment.
Materials And Methods: This cross-sectional study recruited patients suffering from ALPID (exclusion of ALPS) with established genetic diagnosis.
Background: Osteopetrosis is a group of geneticall heterogeneous disorders resulting from impaired osteoclast function and bone resorption. The identification of specific genetic mutations can yield important prognostic and therapeutic implications. Herein, we present the diagnosis and successful application of hematopoietic stem cell transplantation (HSCT) in a patient with osteopetrosis caused by carbonic anhydrase II deficiency (Intermediate osteopetrosis).
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- - The study focused on 16 Iranian patients with very early-onset inflammatory bowel disease (VEO-IBD), aiming to explore the role of underlying genetic issues related to inborn errors of immunity (IEI) in this condition.
- - Most patients were young (median age of 43.5 months), with symptoms starting around 4 months; common signs included chronic diarrhea and perianal diseases, with a notable prevalence of consanguinity among parents.
- - Whole exome sequencing (WES) revealed genetic variants in 81.3% of patients, highlighting notable gene mutations like IL10RB, and emphasizing the need for genetic evaluation in early-onset IBD cases due to the high incidence of mon