Publications by authors named "B Sevastre"
Article Synopsis
- * Binding mechanisms consist of covalent interactions (irreversible) like cross-linking, and non-covalent interactions (reversible) such as intercalation and groove binding.
- * The review emphasizes DNA-metal complex interactions and outlines methods currently used to study these interactions.
Article Synopsis
- Ultrasound-guided kidney biopsy is a crucial diagnostic tool that helps differentiate between acute and chronic kidney diseases in dogs, aiding in accurate diagnosis and treatment decisions.
- A study involving 28 dogs revealed various nephropathy types, with glomerulonephritis being the most common, and highlighted significant effects like increased urinary iNAG levels post-biopsy, indicating kidney damage.
- All dogs experienced some degree of hematuria after the biopsy, which was transient and resolved without treatment, suggesting that while biopsy is invasive, side effects tend to be manageable.
Article Synopsis
- Alzheimer's disease (AD) is the leading cause of dementia among middle-aged and elderly populations, highlighting the need for potential treatments.
- A study analyzed the effects of a leaf extract (BPE) rich in polyphenols and flavonoids on rats with induced AD, assessing both behavioral changes and biochemical markers of oxidative stress and inflammation.
- Results indicated that BPE reduced brain inflammation, lipid peroxidation, and improved cognitive function, suggesting its potential therapeutic benefits for AD.
The discovery of a new non-toxic metal complex with biological activity represents a very active area of research. Two Cu complexes, [Cu(L1)(OH)(DMF)(HO)] (C1) (HL1 = N-(5-ethyl-[1,3,4]-thiadiazole-2-yl)-benzenesulfonamide) and [Cu(L2)(phen)(HO)] (C2) (HL2 = N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)-naphtalenesulfonamide), with two new ligands were synthesized. The X-ray crystal structures of the complexes were determined.
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