[Dependence on benzodiazepine and treatment of withdrawal syndrome].

The 45 patients long-term benzodiazepine users were analyzed because of the diagnosis, the purpose of benzodiazepine onset, the management of benzodiazepine discontinuation and katamnestic examination. Most of the patients suffered from anxiety disorders or mixed anxiety-depressive disorders and they could be successfully with antidepressive drugs treated. Benzodiazepines were also often used without any clinical reason.

[Phototherapy as a supporting treatment in depressive patients].

Effects of treatment of depression with combined antidepressants and phototherapy and antidepressants alone were compared. Phototherapy was applied 5 days a week, up to 1.5 hour a day, 4500 Lux approximately.

[Alprazolam in the treatment of anxiety disorders and mixed anxiety and depressive disorders. Results of multicenter clinical trial].

Alprazolam is one of the most commonly prescribed psychotropics drug all over the world. This suggests that alprazolam is very effective and safe. A multicentre clinical trial was carried out for assessing its efficacy and side effects.

[Weight gain during antidepressant therapy].

Changes of weight were assessed within a population of 329 patients with major depressive disorders and neurotic states, treated with amitriptyline, doxepin, insidone and imipramine. It has been found that the most important increase of body weight occurred in the groups of patients treated with amitriptyline and doxepin. In the group of insidone the increase of weight was not so high as in the previous groups.