Publications by authors named "B Schuessler"

Article Synopsis
  • The study focuses on how Alzheimer's disease (AD) affects decision-making by analyzing neural activity in 5XFAD mice, which have severe amyloid pathology.
  • Using food approach and predator avoidance tasks, the research found that these mice exhibit poor decision-making strategies, with specific neural issues like rigid hippocampal place fields and reduced sharp-wave ripple frequencies.
  • The findings suggest that disruptions in neural connectivity and dynamics are linked to decision-making problems in AD, highlighting opportunities for developing targeted therapies to improve cognitive function.
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Previously, blood and body fluid exposures were managed by a visit to the University Employee Health Clinic during normal business hours and the Emergency Department after hours. We implemented the "S-T-I-C-K" program where health care personnel were evaluated immediately after exposure by a nurse-driven 24/7 hotline. Increasing accessibility to care and a simplified process for exposure management led to a significant decrease in Emergency Department utilization and time between the exposure and receipt of post-exposure prophylaxis.

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We describe the association between job roles and coronavirus disease 2019 (COVID-19) among healthcare personnel. A wide range of hazard ratios were observed across job roles. Medical assistants had higher hazard ratios than nurses, while attending physicians, food service workers, laboratory technicians, pharmacists, residents and fellows, and temporary workers had lower hazard ratios.

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Pavlovian fear conditioning, which offers the advantage of simplicity in both the control of conditional and unconditional stimuli (CS, US) presentation and the analysis of specific conditional and unconditional responses (CR, UR) in a controlled laboratory setting, has been the standard model in basic and translational fear research. Despite 100 years of experiments, the utility of fear conditioning has not been trans-situationally validated in real-life contexts. We thus investigated whether fear conditioning readily occurs and guides the animal's future behavior in an ecologically-relevant environment.

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