Publications by authors named "B Schreiber"
Article Synopsis
- Multiple sclerosis (MS) research often overlooks racial and ethnic minorities, particularly Black or African Americans, who are underrepresented in clinical trials despite significant differences in disease outcomes.
- The EVOLVE-MS-1 study assessed the long-term safety and efficacy of diroximel fumarate in adults with relapsing-remitting MS, focusing on outcomes in Black versus non-Black patients.
- Of the 1057 participants, only 6.8% were Black, with similar levels of adverse effects reported across both groups, though a higher percentage of Black patients discontinued treatment for reasons such as personal choice or adverse events.
Article Synopsis
- Systemic sclerosis complicated by pulmonary arterial hypertension (SSc-PAH) presents significant risks, and this study aimed to evaluate if exercise-based cardiac assessments could predict patient outcomes better than traditional resting measures.
- Fifty intermediate-risk SSc-PAH patients underwent cardio MRI during exercise, finding that most had normal resting cardiac metrics but that peak exercise indicators, specifically RV indexed end-systolic volume (ESVi), were key for predicting survival.
- The study concluded that exercise CMR could help identify patients at higher risk of mortality, enhancing risk assessment practices even when resting tests appear normal.
Imatinib is a chemotherapeutic agent known to cause severe side effects when administrated systemically. Encapsulating imatinib in co-polymer poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) offers a targeted drug delivery. In this work, PLGA 50:50 and PLGA 75:25 NPs encapsulated imatinib using the electrohydrodynamic atomisation technique.
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- The study investigates how heart size and function, measured through cardiovascular magnetic resonance (CMR), can predict outcomes in patients with pulmonary hypertension associated with systemic sclerosis (SSc-PH).
- Out of 148 SSc-PH patients monitored over a median of 3.5 years, 45% died, with findings indicating that older age, right ventricular dilation, and higher native myocardial T1 values were linked to increased mortality risk.
- Importantly, right ventricular end-systolic volume index (RVESVi) and native T1 were identified as independent predictors of mortality, with specific thresholds set for better patient outcomes, highlighting the significance of myocardial tissue characterization in prognosis.
Cancer is one of the most devastating complications of kidney transplantation and constitutes one of the leading causes of morbidity and mortality among solid organ transplantation (SOT) recipients. Immunosuppression, although effective in preventing allograft rejection, inherently inhibits immune surveillance against oncogenic viral infections and malignancy. Adoptive cell therapy, particularly immune effector cell therapy, has long been a modality of interest in both cancer and transplantation, though has only recently stepped into the spotlight with the development of virus-specific T-cell therapy and chimeric antigen receptor T-cell therapy.
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