Controlling the size and elastic modulus of in-aqueous alginate micro-beads.

The fabrication of microgels, particularly those ranging from tens to hundreds of micrometers in size, represents a thriving area of research, particularly for biologists seeking controlled and isotropic media for cell encapsulation. In this article, we present a novel and robust method for producing structurally homogeneous alginate beads with a reduced environmental footprint, employing a co-flow focusing microfluidic device. These beads can be easily recovered in an oil-free aqueous medium, making the fabrication method highly suitable for diverse applications.

iEEG-recon: A fast and scalable pipeline for accurate reconstruction of intracranial electrodes and implantable devices.

Objective: Clinicians use intracranial electroencephalography (iEEG) in conjunction with noninvasive brain imaging to identify epileptic networks and target therapy for drug-resistant epilepsy cases. Our goal was to promote ongoing and future collaboration by automating the process of "electrode reconstruction," which involves the labeling, registration, and assignment of iEEG electrode coordinates on neuroimaging. We developed a standalone, modular pipeline that performs electrode reconstruction.

Resting-state background features demonstrate multidien cycles in long-term EEG device recordings.

Background: Longitudinal EEG recorded by implanted devices is critical for understanding and managing epilepsy. Recent research reports patient-specific, multi-day cycles in device-detected epileptiform events that coincide with increased likelihood of clinical seizures. Understanding these cycles could elucidate mechanisms generating seizures and advance drug and neurostimulation therapies.

Thermal Antibubbles: When Thermalization of Encapsulated Leidenfrost Drops Matters.

Antibubbles are ephemeral objects composed of a liquid drop encapsulated by a thin gas shell immersed in a liquid medium. When the drop is made of a volatile liquid and the medium is superheated, the gas shell inflates at a rate governed by the evaporation flux from the drop. This thermal process represents an alternate strategy for delaying the antibubble collapse.

The seizure severity score: a quantitative tool for comparing seizures and their response to therapy.

Epilepsy is a neurological disorder characterized by recurrent seizures which vary widely in severity, from clinically silent to prolonged convulsions. Measuring severity is crucial for guiding therapy, particularly when complete control is not possible. Seizure diaries, the current standard for guiding therapy, are insensitive to the duration of events or the propagation of seizure activity across the brain.