Publications by authors named "B Schaub"
Background: Humans are subjected to various environmental stressors (bacteria, viruses, pollution) throughout life. As such, an inherent relationship exists between the effect of these exposures with age. The impact of these environmental stressors can manifest through DNA methylation (DNAm).
View Article and Find Full Text PDFArticle Synopsis
- This study investigates how farm dust may provide asthma protection in children by analyzing the immune responses of allergic asthmatics and healthy controls at a single-cell level.
- Researchers used mass cytometry to measure changes in immune cell types and their activity after exposure to farm dust, finding significant changes in both innate and adaptive immune cells.
- The results indicated that farm-dust exposure reduces asthma-related immune markers and alters T-cell and B-cell functions, suggesting potential mechanisms for the protective effects observed in children exposed to farm environments.
Article Synopsis
- - The study investigates how early-life risk factors from both host and environment interact with an infant's respiratory system to influence the development of wheezing and asthma over time.
- - Researchers analyzed data from two large cohorts of healthy infants (BILD and PASTURE) to identify the effects of various factors on wheezing and asthma outcomes, specifically tracking symptom severity scores over the first year of life.
- - Findings showed a complex dynamic interplay between different risk factors and breathing symptoms, ultimately highlighting the importance of these interactions in predicting respiratory health outcomes in young children.
Introduction: Eosinophil-derived neurotoxin (EDN) is a biomarker for eosinophilic activation. Urinary (u) EDN may allow non-invasive monitoring of asthma, but clinical recommendations are lacking. We assessed the potential of uEDN as a marker of disease activity in pediatric asthma.
View Article and Find Full Text PDF