RIMD: A novel method for clinical prediction.

Electronic health records (EHR) are sparse, noisy, and private, with variable vital measurements and stay lengths. Deep learning models are the current state of the art in many machine learning domain; however, the EHR data is not a suitable training input for most of them. In this paper, we introduce RIMD, a novel deep learning model that consists of a decay mechanism, modular recurrent networks, and a custom loss function that learns minor classes.

Polymorphic ventricular tachycardias induced by D-sotalol and phenylephrine in canine preparations of atrioventricular block: initiation in the conduction system followed by spatially unstable re-entry.

Objective: Polymorphic ventricular tachycardias (PVT) occur spontaneously in canine hearts under the combination of D-sotalol (S), bradycardia and phenylephrine (PE). We investigated the hypotheses that: (1) the activation patterns of the initial PVT beats would be consistent with an origin in the ventricular conduction system; and (2) the inhomogeneous prolongation of repolarisation intervals can provide refractory barriers for re-entrant activity.

Methods: Unipolar electrograms were recorded from 127 epicardial (EPI) sites with a sock electrode array as well as from intramural and endocardial sites during PVTs.

A quantitative description of the E-4031-sensitive repolarization current in rabbit ventricular myocytes.

We have measured the E-4031-sensitive repolarization current (IKr) in single ventricular myocytes isolated from rabbit hearts. The primary goal of this analysis was a description of the IKr kinetic and ion transfer properties. Surprisingly, the maximum time constant of this component was 0.

The role of prostanoids in neonatal cerebral blood flow autoregulation.

The regulatory role of prostanoids in acute cerebrovascular adaptations in newborns was determined using awake neonatal piglets (ages 0-5 days, n = 60). Cerebral blood flow (CBF) was measured by radiolabelled microspheres before and 45 s after intracarotid injections of PGE1 (0.1-10 micrograms/kg, n = 6), PGE2 (0.

Frequency and voltage-dependent effects of mono-N-dealkyldisopyramide, the major metabolite of disopyramide, in canine ventricular tissue.

Mono-N-dealkyldisopyramide (MND), the major metabolite of disopyramide, reaches significant concentrations in patients; however, the contribution of MND to the antiarrhythmic or toxic effects of disopyramide is not known. We assessed the kinetics and magnitude of interaction of MND with the sodium channel in canine ventricular tissue superfused in vitro using Vmax as an index of sodium channel block. At a basic cycle length of 1000 msec, MND (4-32 micrograms/ml) produced a concentration-dependent depression of both Vmax and amplitude of the action potential and accelerated all phases of repolarization in Purkinje fibers.