Effect of carnitine on Hariana bull spermatozoa function after cryopreservation.

Background: Carnitine reduces reactive oxygen species-induced apoptosis and DNA fragmentation through its antioxidant effect.

Objective: To investigate the effect of carnitine on capacitation, mitochondrial activity, acrosomal integrity, reactive oxygen species (ROS), membrane fluidity, and DNA fragmentation during the cryopreservation of Hariana bull spermatozoa.

Materials And Methods: Thirty-two semen ejaculates were obtained using artificial vagina (AV) from four seemingly healthy Hariana bulls.

Cost-effectiveness of shared decision-making in determining challenge setting for nonsevere food protein-induced enterocolitis syndrome.

Background: Food protein-induced enterocolitis syndrome (FPIES) affects approximately 0.5% of US children. Oral food challenges (OFCs) are frequently conducted to assess FPIES resolution in an observed setting, given the risk of severe reactions.

An update on current type 2 diabetes mellitus (T2DM) druggable targets and drugs targeting them.

Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and affects millions of people globally. Even after advancement and development in medical science, it is a big task to achieve victory over type 2 diabetes mellitus (T2DM). T2DM can be a reason for fatal events like stroke, cardiac failure, nephropathy, and retinopathy.

Artificial Intelligence in Healthcare: Balancing Technological Innovation With Health and Care Workforce Priorities.

Artificial Intelligence (AI) has emerged as a transformative force in healthcare, offering significant potential to address workforce challenges and improve patient outcomes. This perspective article presents a framework for responsible AI innovation, emphasising ethical governance, responsible leadership and a commitment to human-centred AI. It provides guidance for healthcare organisations to position AI as a strategic enabler, augmenting the health and care workforce and fostering sustainable, patient-centred advancements in healthcare.

Beyond the genome: unveiling tissue-specific non-coding RNAs in clove ().

Clove (), valued for its role in food preservation and medicine, has recently drawn research interest for its noncoding RNAs (ncRNAs). This study discovers 3274 long noncoding RNAs (lncRNAs) and 2404 circular RNAs (circRNAs) from publicly available RNAseq data. We identified the regulation of 834 genes through miRNA-lncRNA-mRNA network interactions.