Publications by authors named "B Santinello"
Article Synopsis
- Centromeres require the histone variant CENP-A for their function and inheritance, while the role of centromeric DNA repeats is still being investigated.
- Recent research focuses on a centromere-specific retroelement, which contributes significantly to the centromeric transcriptome and produces RNAs that localize to centromeres during cell division.
- The study suggests that this retroelement enhances the maintenance of centromeres by promoting transcription and is preferentially found within CENP-A-containing chromatin, highlighting its potential evolutionary significance across species.
Crosses between closely related species of frogs result in inviable embryos that die following catastrophic cell divisions. A new study identifies defects in centromere maintenance and DNA replication stress as key forces driving this incompatibility.
View Article and Find Full Text PDFCentromeres are essential chromosomal regions that mediate kinetochore assembly and spindle attachments during cell division. Despite their functional conservation, centromeres are among the most rapidly evolving genomic regions and can shape karyotype evolution and speciation across taxa. Although significant progress has been made in identifying centromere-associated proteins, the highly repetitive centromeres of metazoans have been refractory to DNA sequencing and assembly, leaving large gaps in our understanding of their functional organization and evolution.
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