Publications by authors named "B Sanford"
Article Synopsis
- Gene expression helps cells adapt to stress, and a specific protein called P-TEFb plays a big role in how cells respond to heat and other stressors.
- Researchers found that when pediatric brain cancer cells are treated with radiation, P-TEFb helps the cells quickly reorganize their DNA to repair damage and keep living.
- Blocking P-TEFb while giving radiation treatment weakened the cells’ ability to adapt, making them more likely to die and improving survival time in experiments.
Article Synopsis
- * The study evaluated 1,048 SNPs from 59 DNA repair genes in 46 pediatric patients, linking certain SNPs (from CYP29, XRCC1, and BRCA1) to lower IQ scores irrespective of radiation type.
- * Findings suggest that identifying these SNPs could help predict cognitive outcomes in brain tumor survivors, emphasizing the need for future research on larger populations to enhance treatment strategies and cognitive support.
Purpose: Neurocognitive deficits are common in pediatric brain tumor survivors. The use of single nucleotide polymorphism (SNP) analysis in DNA repair genes may identify children treated with radiation therapy for brain tumors at increased risk for treatment toxicity and adverse neurocognitive outcomes.
Methods: The Human 660W-Quad v1.
Preventable vitamin D deficiency (VDD) is a global health concern. The prevention, early detection, and treatment of vitamin D deficiency aligning with serum 25-hydroxyvitamin D concentration recommendations of 40-60 ng/mL (100-150 nmol/L), provided by an international panel of 48 vitamin D researchers, would result in significant health benefits and cost savings to individuals and society. However, research shows that healthcare professionals lack knowledge and confidence in best practices with respect to vitamin D.
View Article and Find Full Text PDF