Publications by authors named "B Samans"
Kidney injury is a significant complication in end-stage liver disease (ESLD), leading to increased morbidity and mortality. While liver transplant alone (LTA) can promote kidney recovery (KR), non-recovery associates with adverse outcomes, but the underlying pathophysiology is still unclear. We studied 10 LTA recipients with or without kidney failure (KF) and measured serum levels of OPN and TIMP-1 (previously identified predictors of KR), 92 proinflammatory proteins (Olink), and urinary cell populations.
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- Clinical trials often face cancellations due to insufficient participants, leading to the development of Clinical Trial Recruitment Support Systems like ATLAS, which helps identify suitable subjects by utilizing medical classification systems.
- The study assessed ATLAS's effectiveness in managing 223 eligibility criteria from 30 recent trials, revealing that 51% of inclusion criteria were fully implementable, with 10% of trials entirely portrayable in the software.
- The research highlighted the need for collaboration with clinical personnel to enhance the accuracy of criteria definitions and expand the range of implementable criteria in clinical studies.
Objectives: Immune monitoring is an important aspect in diagnostics and clinical trials for patients with compromised immune systems. Flow cytometry is the standard method for immune cell counting but faces limitations. Best practice guidelines are available, but lack of standardization complicates compliance with e.
View Article and Find Full Text PDFBackground: The course of COVID-19 is associated with severe dysbalance of the immune system, causing both leukocytosis and lymphopenia. Immune cell monitoring may be a powerful tool to prognosticate disease outcome. However, SARS-CoV-2 positive subjects are isolated upon initial diagnosis, thus barring standard immune monitoring using fresh blood.
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