Who Are Suitable Patients for Omitting Breast Surgery as an Exceptional Responder in Selected Molecular Subtypes of Breast Cancer After Neoadjuvant Systemic Treatment?

: Among breast cancer molecular types, HER2 positive and triple negative (TN) subtypes have the highest likelihood of pathological complete response (pCR), which is a surrogate marker for reduced recurrence and improved patient survival after neoadjuvant systemic treatment (NST). Preoperative pathological identification of these exceptional responders is a new era. Therefore, we aimed to determine the accuracy of trucut biopsy in identifying the exceptional responders in selected molecular subtypes of breast cancer patients.

The influence of unstable surfaces on ankle muscle activation during functional exercises.

Background: The study aims to compare how 3 balance platform designs affect ankle muscle activation during various functional exercises, all performed on the dominant limb.

Methods: Fifteen healthy, active participants performed single-leg stance, single-leg squat, and forward lunge on BOSU® Ball, wobble board, stability trainer, and flat ground. Surface electromyography was used to measure Peroneus Longus, Tibialis Anterior, Gastrocnemius, and Soleus activation during these exercises on different platforms and flat ground.

Baseline capillaroscopy provides no evidence of microvascular changes to predict long-COVID syndrome.

Background: Long-COVID refers to a variety of symptoms that continue for at least 4 weeks following the onset of acute COVID-19 infection. "Microclots/microvasculopathy" is a potential cutting-edge theory. Nailfold capillaroscopy is a non-invasive method used to assess microvascularity.

Possible role of endoplasmic reticulum stress in the pathogenesis of chronic adenoiditis and adenoid hypertrophy: A prospective, parallel-group study.

Background: Adenoid tissue is a first-line host defense secondary lymphoid organ, especially in childhood. The endoplasmic reticulum (ER) is required to maintain balanced cellular activity. With impaired ER functions, protein accumulation occurs, resulting in ER stress, which plays a role in the etiopathogenesis of many diseases.