PARP inhibition radiosensitizes BRCA1 wildtype and mutated breast cancer to proton therapy.

Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that generates more DNA damage in the tumor than standard radiotherapy using photons. Two human BRCA1-mutated breast cancer cell lines and their isogenic BRCA1-recovered pairs were treated with a PARP inhibitor and irradiated with photons or protons.

Obesity modulates NK-cell activity via LDL & DUSP1 signaling for Populations with Adverse Social Determinants.

African American (AA) women are disproportionally affected by obesity and hyperlipidemia, particularly in the setting of adverse social determinants of health (aSDoH) contributing to health disparities. Obesity, hyperlipidemia, and aSDoH appear to impair Natural Killer cells (NKs). As potential common underlying mechanisms are largely unknown, we sought to investigate common signaling pathways involved in NK dysfunction related to obesity and hyperlipidemia in AA women from under-resourced neighborhoods.

Effects of sodium bisulfate or sodium sesquicarbonate as a sodium source in broiler chicken diets with or without a coccidiosis challenge.

Broilers commonly experience stressors such as coccidiosis, a parasitic infection that results in intestinal damage, malabsorption, and performance losses. The poultry industry is exploring alternatives to anticoccidials for controlling coccidiosis, especially through the enhancement of gut health. Sodium bisulfate (NaHSO; SBS), an acid salt, has been used for many years as a litter acidifier to reduce aerial ammonia in poultry housing.

Phytoremediation evaluation of forever chemicals using hemp (Cannabis sativa L.): Pollen bioaccumulation and the risk to bees.

Per- and polyfluoroalkyl substances (PFAS), often termed "forever chemicals," are a diverse group of persistent fluorinated compounds, including the well-known perfluorooctanesulfonic acid (PFOS), which has been identified as lethal to bee larvae. However, the risk of PFAS exposure through pollen, a bee's primary food source, has not been thoroughly investigated. In controlled greenhouse experiments, Cannabis sativa L.