Independent Validation of a HER2-low Focused IHC Scoring System for Enhanced Pathologist Precision and Consistency.

For two decades the ASCO CAP HER2 testing criteria have included 0 and 1+ scores, but this distinction was inconsequential. Now, based on the DESTINY Breast-04 Trial (DB-04) results, for patients with metastatic breast cancer it underpins eligibility for T-DXd treatment. Discerning 0 from 1+ IHC staining is challenging, as HER2 low is not a biologically distinct cancer subset, there are no reference standards or controls and second-tier tests do not apply.

Assessing the impact of railway noise on human health and daily life: a structural equation model approach for transportation and environmental planning.

Rapid urbanization has led to unplanned settlements near railway lines, exposing residents to continuous noise pollution with potential adverse effects on health. This study focuses on the environmental monitoring and assessment of railway noise pollution in urban areas and its impact on human health and daily activities. Noise levels were quantified across different residential zones using precise sound level meters, and a detailed human perception survey was conducted to assess the relationship between noise exposure, annoyance, and health disturbances.

The Root-Tuber Trypsin Inhibitor of Winged Bean and Its Anti-cancerous Activity Against Osteosarcoma Cell-Line.

Trypsin inhibitor from the root-tuber of underutilized legume Winged bean (Psophocarpus tetragonolobus (L.) DC.) (WbT-TI) was purified using ion exchange chromatography followed by size-exclusion chromatography.

A Standardized Extract Improves Knee Joint Function and Cartilage Morphology in Human Volunteers with Mild to Moderate Osteoarthritis in a Randomized Placebo-Controlled Study.

Background And Objective: Roxb. ex Colebr. (Family: Burseraceae; Genus: Boswellia) gum resin (Salai guggul) has profound therapeutic value in Ayurvedic and Unani medicines in alleviating several chronic inflammatory illnesses, including arthritis, asthma, skin and blood diseases, fever, etc.

Novel rhodanine-thiazole hybrids as potential antidiabetic agents: a structure-based drug design approach.

New rhodanine-thiazole clubbed compounds (7a-7l) were synthesised and characterised with various spectroscopy methods. The synthesised hybrids underwent HPA, HLAG inhibition, and peroxisome proliferator-activated receptor-gamma (PPAR-γ) expression assays. Through the biological study, compound 7f showed promising inhibitory activity against HPA with an IC value of 27.