Publications by authors named "B S Saravanan"
Immunosenescence, the slow degradation of immune function over time that is a hallmark and driver of aging, makes older people much more likely to be killed by common infections (such as flu) than young adults, but it also contributes greatly to rates of chronic inflammation in later life. Such micro nutrients are crucial for modulating effective immune responses and their deficiencies have been associated with dysfunctional immunity in the elderly. In this review, we specifically focused on the contribution of major micro nutrients (Vitamins A, D and E, Vitamin C; Zinc and Selenium) as immunomodulators in ageing population especially related to inflame-ageing process including autoimmunity.
View Article and Find Full Text PDFIntroduction: Globally, ticks rank second only to mosquitoes as vectors of deadly pathogens affecting humans and first in transmitting animal pathogens, presenting a significant challenge to human wellness and sustainability of livestock-based industries. Traditional tick control via chemical acaricides impacts on the environment and has led to the emergence of multi-acaricide-resistant tick populations. Use of immunoprophylactic, along with other components of integrated tick management, holds the potential to mitigate tick infestations in a sustainable manner.
View Article and Find Full Text PDFIn this study, garlic-oil-combined cellulose fibers were prepared by using Borassus flabellifer (Asian Palmyra palm) to enhance the post-harvest shelf life of tomatoes. The physicochemical properties of the prepared cellulose fibers were characterized by using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (FE-SEM). The B.
View Article and Find Full Text PDFArticle Synopsis
- * Traditional diagnostic methods for cysticercosis lack sensitivity and require specialized labs, making effective disease control challenging.
- * A new recombinant Ag2-based dot blot assay was developed, showing high sensitivity (89%) and specificity (100%), indicating it could be a cost-effective and reliable diagnostic tool for use in low-resource settings.
Article Synopsis
- Transcription factors like estrogen receptor α (ERα) regulate gene expression by binding to DNA and can interact with RNA, which may influence their binding to chromatin.
- This study found that RNA binding is crucial for maintaining proper recruitment of ERα to DNA, especially at weaker binding sites, and without this RNA interaction, ERα becomes more mobile in the nucleus.
- Increased mobility of ERα leads to enhanced transcription of genes with low-strength motifs, but stable binding at stronger sites may hinder ligand-dependent gene expression, suggesting RNA interactions help balance transcription regulation.