SARM1 deletion inhibits astrogliosis and BBB damage through Jagged-1/Notch-1/NF-κB signaling to improve neurological function after ischemic stroke.

Reactive astrogliosis is a critical process in the development of ischemic stroke. However, the precise mechanism by which reactive astrogliosis changes the pathogenesis of ischemic stroke remains elusive. Sterile alpha and TIR motif-containing 1 protein (SARM1) plays a key role in axonal degeneration and is involved in different cell death programs that regulate neuronal survival.

Rapid analysis of Δ8-tetrahydrocannabinol, Δ9-tetrahydrocannabinol, and cannabidiol in Δ8-tetrahydrocannabinol edibles by Ag(I) paper spray mass spectrometry after simple extraction.

Δ8-Tetrahydrocannabinol (THC) products are increasingly popular despite uncertainties regarding their legality and safety. Based on the hypothesis that unique double-stage tandem mass spectrometry (MS) and triple-stage tandem mass spectrometry (MS) fragments would allow unambiguous identification of cannabinoids, a simple and rapid method was developed for the differentiation of Δ8-THC, Δ9-THC, and cannabidiol (CBD) within 1 min. This approach combines methanol extraction and silver(I)-impregnated paper spray mass spectrometry (AgPS-MS) for the analysis of Δ8-THC products.

Pan-cancer analysis predicts MBOAT2 as a potential new ferroptosis related gene immune checkpoint.

Background: The phospholipid-modifying enzyme MBOAT2 plays a crucial role in iron homeostasis by inhibiting iron sequestration, thus preventing iron-induced cell death. It achieves this by remodeling the phospholipid composition of cell membranes through phospholipid metabolism. Although multiple studies have highlighted the significance of MBOAT2 in tumorigenesis, a comprehensive pan-cancer analysis has not been conducted to date.

Cajanus cajan (L.) Millsp. Leaves: A Comprehensive Review of Phytochemistry, Pharmacological Properties, Safety, and Clinical Applications.

Cajanus cajan (L.) Millsp. leaves (CCML), a well-known traditional Chinese medicine, is widely recognized for its protective effects against osteoporosis and osteonecrosis.

Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.

Background And Aims: Antioxidants, including vitamin E (VE) and grape seed extract (GSE), as anti-aging supplementation have been widely used to improve human health. The gut microbiota plays a crucial role in health and affects the treatment effect of various interventions. However, the role of gut microbiota in VE remains unclear.