Impact of Social Determinants of Health on Pre-exposure Prophylaxis Care for HIV Prevention.

Background: HIV continues to disproportionately impact men who have sex with men (MSM) in the United States (US). Pre-exposure prophylaxis (PrEP) is effective, but disparities persist. Limited studies have conducted systematic evaluations of social determinants of health (SDOH) and their effects on PrEP persistence among MSM.

Bacteroides expand the functional versatility of a conserved transcription factor and transcribed DNA to program capsule diversity.

The genomes of human gut bacteria in the genus Bacteroides include numerous operons for biosynthesis of diverse capsular polysaccharides (CPSs). The first two genes of each CPS operon encode a locus-specific paralog of transcription elongation factor NusG (called UpxY), which enhances transcript elongation, and a UpxZ protein that inhibits noncognate UpxYs. This process, together with promoter inversions, ensures that a single CPS operon is transcribed in most cells.

Assessment of the expression levels of two long non-coding RNAs, lnc-CYP11A1-1 and RP11573D15.8, in human aneuploid and euploid embryos.

Introduction: Long non-coding RNAs (lncRNAs) are a subset of RNA molecules that have been shown to be involved in gene regulation. A lot of different pathways are involved during gametogenesis and any disturbance to these pathways may have a derogatory impact on producing a haploid gamete and thus a euploid embryo. Steroidogenesis pathway plays a crucial role in gametogenesis.

Initiating and Sustaining GSAs Across the District as Part of a Vision for Equity: A Case Study in Chicago Public Schools.

Background: Increasingly, there are calls for educational equity to explicitly include LGBTQ+ students, including the creation of lesbian, gay, bisexual, transgender, or queer/questioning (LGBTQ+) clubs, or Genders and Sexualities Alliances (GSAs), which are associated with positive outcomes for LGBTQ+ students and promote a safer school climate for all students. However, less is known about strategies to initiate and sustain GSAs. Chicago Public Schools (CPS) serves as a case study of how to embrace LGBTQ+ equity through an evaluation of its current practices to support GSAs.