Biomechanical Evaluation of the Sheep Common Peroneal Nerve After Crush Injury.

Axonotmesis, a common peripheral nerve injury in humans and animals, leads to significant biomechanical and physiological consequences. The lack of a standardized crushing protocol for complex animal models limits research and therapeutic translations for humans and clinically relevant animal species. This study aimed to assess the impact of different crushing forces on the biomechanical behavior of the sheep common peroneal nerve and to establish a force for standardized in vivo protocols.

evaluation of dental pulp stem cells for sciatic nerve regeneration: foundations for future applications.

Introduction: Peripheral nerve injuries, resulting from trauma or medical interventions, present significant clinical challenges due to their severe physiological and functional impacts. Despite various therapeutic approaches, optimal methods for promoting nerve regeneration remain difficult to obtain. This study is a preliminary step towards the future use of chitosan nerve guide conduits combined with human dental pulp stem cells and their conditioned media to promote nerve regrowth in a rat model with severe sciatic nerve damage.

Honey, Gellan Gum, and Hyaluronic Acid as Therapeutic Approaches for Skin Regeneration.

: Chronic wounds pose a significant health concern, with their prevalence increasing due to various etiologies. The global aging population further contributes to this rise, placing a substantial burden on healthcare systems in developed countries. This work aimed to develop new therapeutic options in the form of creams and dressings based on honey, gellan gum, and hyaluronic acid for preventing and treating chronic wounds across all stages.

Solvatochromic fluorophores based on 6-fluoro-2-(aryl)quinoline-4-carboxylic acids: Synthesis, optical studies and evaluation of their antimicrobial and larvicidal properties.

6-Fluoro-2-(aryl)quinoline-4-carboxylic acids 1-11 were synthesized via Pfitzinger reactions between 5-fluoroisatin and methyl aryl ketones. The molecules were studied regarding the impact of their substituent patterns (a-e) on their optical and bioactivity properties. All compounds were fluorescent in solution and had significant solvatochromic behavior, measured in tetrahydrofuran, dichloromethane, dimethylsulfoxide, acetonitrile, methanol, and water at different pHs.

Macro- and microscopic morphology of the rectal gland of the Brazilian guitarfish (Pseudobatos horkelii) from Southeastern Brazil.

Sharks and rays present an osmoregulatory mechanism essentially exercised by a rectal salt gland. Histological assessments of this gland, however, are notoriously lacking. In this sense, histological assessments of the rectal gland of the Brazilian guitarfish, Pseudobatos horkelii obtained from off the coast of Rio de Janeiro, Brazil, were carried out herein.