Publications by authors named "B S Kangarloo"
Background: Hematopoietic stem cell transplantation can be curative for children with difficult-to-treat leukemia. The conditioning regimen utilized is known to influence outcomes. We report outcomes of the conditioning regimen used at the Alberta Children's Hospital, consisting of busulfan (with pharmacokinetic target of 3750 μmol*min/L/day ±10%) for 4 days, higher dose (250 mg/m ) fludarabine and 400 centigray (cGy) of total body irradiation.
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- - Acute Graft versus Host Disease (aGVHD) is a common complication in allogeneic hematopoietic stem cell transplantation, initiated by donor T cells attacking the recipient's tissues, particularly affecting the skin, liver, and gastrointestinal tract.
- - The study investigated the genetic factors influencing aGVHD severity in pediatric patients through an exome-wide association study, identifying significant associations with four specific gene variants: ERC1, PLEK, NOP9, and SPRED1.
- - Findings indicate that certain genetic variants, particularly ERC1 and PLEK, are linked to higher risks of moderate to severe aGVHD independently of other non-genetic factors, highlighting the role of genetics in transplant outcomes.
Article Synopsis
- Sinusoidal obstruction syndrome (SOS) is a serious problem that can happen after a special medical treatment called hematopoietic stem cell transplantation (HSCT) due to damage in liver cells.
- Researchers studied the genes of children who went through HSCT to find out more about why some get SOS, focusing on specific genetic changes called single-nucleotide polymorphisms (SNPs).
- They found three important SNPs linked to a higher risk of SOS, which could help doctors create personalized treatments to prevent or treat this condition better in the future.
Background: Mesna is a sulfohydrate administered as a supportive drug in conjunction with oxazaphosphorines to prevent bladder toxicity from metabolites. When oxazaphosphorines are given simultaneously with platinum drugs, Mesna binds with platinum drugs as well. Previously we showed in cell culture, that Mesna reduces the efficacy of some platinum drugs.
View Article and Find Full Text PDFBackground: Malignant glioma are often resistant to cisplatin. Numerous chemical modifications have been made to overcome this limitation. Analyzing such novel compounds, we previously hypothesized, that hydrophobicity improves the cytotoxicity of NH3 substituted platinum agents.
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