Noninvasive imaging biomarker reveals invisible microscopic variation in acute ischaemic stroke (≤ 24 h): a multicentre retrospective study.

To develop and validate non-contrast computed tomography (NCCT)-based radiomics method combines machine learning (ML) to investigate invisible microscopic acute ischaemic stroke (AIS) lesions. We retrospectively analyzed 1122 patients from August 2015 to July 2022, whose were later confirmed AIS by diffusion-weighted imaging (DWI). However, receiving a negative result was reported by radiologists according to the NCCT images.

Ultrasensitive Flexible NO Sensors with Remote-Controllable ADC-Electropolymerized Conducting Polymers on Plastic.

Alternating- and direct-current (ADC) bipolar electropolymerization (EP) offers an efficient and scalable approach for the lateral synthesis of conjugated macromolecules, enabling the simultaneous polymerization and deposition of large conducting polymer films with intriguing fractal-like ramified topographies onto arbitrary insulating substrates under remote control. In this study, we presented the remote synthesis of poly(3,4-ethylenedioxythiophene) (PEDOT):anion sensing films on a plastic substrate, aimed at their use in flexible nitrogen dioxide (NO) gas sensors. Notably, the PEDOT:ClO films exhibited excellent gas-sensing characteristics, with a sensitivity of 54.

Ultrasound-Activated Copper Matrix Nanosonosensitizer for Cuproptosis-Based Synergy Therapy.

Cuproptosis exhibits enormous application prospects in treatment. However, cuproptosis-based therapy is impeded by the limited intracellular copper ions, the nonspecific delivery, uncontrollable release, and chelation of endogenous overproduced glutathione (GSH). In this work, an ultrasound-triggered nanosonosensitizer (p-TiO-Cu(I)) was constructed for Cu(I) delivery, on-demand release, GSH consumption, and deeper tissue response.

Diagnostic cholangioscopy for surgical planning of extrahepatic cholangiocarcinoma.

The recent clinical outcomes of multi-regimen chemotherapy included prolonged survival and a high rate of conversion to surgery in Asian patients with advanced biliary tract cancer. The ability of single-operator cholangioscopy (SOC) to detect and stage extrahepatic cholangiocarcinoma (CCC) in intraductal lesions is becoming more important in determining the extent of surgery. The aim of this study was to evaluate the role of SOC in surgical planning for extrahepatic CCC.

THz-induced gas alignment in dispersionless field enhancing waveguides.

We demonstrate a versatile THz waveguide platform for tailored THz-induced orientation and alignment of gas molecules. The underlying waveguide structure is dispersionless, with a refractive index close to one, and enhances the electric as well as the magnetic field up to a factor of five. These properties increase the detected transient birefringence signal by more than an order of magnitude compared to conventional THz free space focusing.