Publications by authors named "B S Jani"
Background: Identifying clusters of multiple long-term conditions (MLTCs), also known as multimorbidity, and their associated burden may facilitate the development of effective and cost-effective targeted healthcare strategies. This study aimed to identify clusters of MLTCs and their associations with long-term health-related quality of life (HRQoL) in two UK population-based cohorts.
Methods: Age-stratified clusters of MLTCs were identified at baseline in UK Biobank (n = 502,363, 54.
Background: Socioeconomic inequality in infant mortality in the UK is rising. This study aims to identify contributory maternal and pregnancy factors that can explain the known association between area deprivation and infant mortality.
Methods: A cohort study was conducted using Clinical Practice Research Datalink (CPRD) primary care data between 2004 and 2019 linked to the Index of Multiple Deprivation (IMD), and infant mortality from the Office for National Statistics death data.
Introduction: Clinical guidelines recommend the use of the kidney failure risk equation (KFRE) to guide the referral of individuals with chronic kidney disease (CKD) to secondary kidney care services. People living with CKD frequently experience multiple long-term conditions (multimorbidity) and/or frailty. This may impact patients' or carers' perceptions of kidney failure in the context of other health problems and associated risks and emphasises the need for shared decision-making.
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- Prognostic models for chronic kidney disease (CKD) are essential for identifying at-risk patients and enabling precision medicine, but they often fail to consider multimorbidity and frailty.
- A systematic review found that out of 97 studies on kidney failure models, only a few reported on multimorbidity and none adequately included frailty in their assessments.
- The lack of studies addressing these factors limits the evidence-based guidance for treating patients with CKD who have multiple health issues, highlighting a critical area for future research.