Publications by authors named "B S Hough"
Article Synopsis
- This study explores the diversity of mycoviruses within the Ceratocystidaceae family by analyzing 10 fungal transcriptomes, revealing six novel mycoviruses.
- The newly discovered mycoviruses are primarily positive sense single-stranded RNA viruses belonging to the Mitoviridae family, with some double-stranded RNA viruses linked to the Totiviridae family.
- Notably, an identical mycovirus was found in two different fungal species from distinct locations, suggesting possible transmission routes, and expanding the known host range of mycoviruses in this fungal family.
New and developing first line pharmacotherapies for treating non-Hodgkin lymphoma.
Expert Opin Pharmacother
August 2024
Introduction: Non-Hodgkin lymphomas (NHLs) encompass a wide range of diseases from precancerous states such as monoclonal B-cell lymphocytosis to the rapidly growing Burkitt lymphoma. In 2022, we witnessed two new classifications for these malignant lymphoid tumors: The World Health Organization (WHO) 5th edition Classification of Haematolymphoid Tumours and the International Consensus Classification of Mature Lymphoid Neoplasms (ICC).
Areas Covered: Given our improved understanding of the mechanisms underlying lymphomagenesis at the molecular level, several novel agents have been or are being actively developed, including targeted therapies and immunotherapies.
Mycoviruses (viruses of fungi) are ubiquitous throughout the fungal kingdom and are currently classified into 23 viral families and the genus by the International Committee on the Taxonomy of Viruses (ICTV). The primary focus of mycoviral research has been on mycoviruses that infect plant pathogenic fungi, due to the ability of some to reduce the virulence of their host and thus act as potential biocontrol against these fungi. However, mycoviruses lack extracellular transmission mechanisms and rely on intercellular transmission through the hyphal anastomosis, which impedes successful transmission between different fungal strains.
View Article and Find Full Text PDFAn miRNA Signature Predicts Grading of Pancreatic Neuroendocrine Neoplasms.
Cancer Genomics Proteomics
March 2023
Background/aim: Grading pancreatic neuroendocrine neoplasms (PNENs) via mitotic rate and Ki-67 index score is complicated by interobserver variability. Differentially expressed miRNAs (DEMs) are useful for predicting tumour progression and may be useful for grading.
Patients And Methods: Twelve PNENs were selected.