Mycobacterial Small Heat Shock Proteins: Dissecting Their Roles in Pathogenesis and Development of Therapeutics.

Small heat shock proteins are a ubiquitous family of molecular chaperones. This class of proteins has a conserved α-crystallin domain. , the etiological agent that causes tuberculosis (TB), harbors two α-crystallin-related (Acr) small heat shock proteins, Acr1 (Hsp16.

Genetic diversity in the IIS6 domain of voltage gated sodium channel gene among Aedes aegypti populations from different geographical regions in India.

This study provides critical insights into the genetic diversity of the IIS6 domain of the Voltage Gated Sodium Channel (VGSC) gene in Aedes aegypti populations across various regions in India, focusing on two mutations: S989P and V1016G. Samples were collected from seven different cities across the country, including Dibrugarh, Kolkata, Berhampur, Bhopal, Bengaluru, Ghaziabad, and Aurangabad. The IIS6 domain was amplified and sequenced, revealing that the V1016G mutation was found at a higher frequency compared to the S989P mutation.

Knowledge Models for Cancer Clinical Practice Guidelines: Construction, Management and Usage in Question Answering.

An automated knowledge modeling algorithm for Cancer Clinical Practice Guidelines (CPGs) extracts the knowledge contained in the CPG documents and transforms it into a programmatically interactable, easy-to-update structured model with minimal human intervention. The existing automated algorithms have minimal scope and cannot handle the varying complexity of the knowledge content in the CPGs for different cancer types. This work proposes an improved automated knowledge modeling algorithm to create knowledge models from the National Comprehensive Cancer Network (NCCN) CPGs in Oncology for different cancer types.

HIV associated motor neuron disease (MND): A case series with systematic review of literature.

Human immunodeficiency virus (HIV) associated motor neuron disease (MND) is very rare. HIV infection can cause an MND-like syndrome due to central nervous system (CNS) involvement de novo or during antiretroviral therapy (ART) due to CNS escape. We present two cases: one with a classic amyotrophic lateral sclerosis (ALS) phenotype, which was the manifestation of symptomatic CNS escape from ART, and the second with a primary lateral sclerosis (PLS) phenotype associated with underlying HIV infection.

Efficacy and safety of ayurvedic intervention (Sarpgandha Mishran) vs amlodipine for Stage-I primary hypertension- study protocol for a prospective Double-Dummy, Double-Blind, placebo-controlled Randomized Clinical Trial.

Background: Hypertension presents as a modifiable risk factor for cardiovascular diseases, with approximately two-thirds of the global hypertensive population concentrated in low- and middle-income nations. Sarpagandha Mishran is an Ayurveda intervention utilized for the management of hypertension. The objective of the study is to assess the clinical efficacy and safety of Sarpgandha Mishran in the Management of Stage-I Hypertension.