Effect of hydrocortisone on spontaneous and mitogen-dependent activity of peripheral blood lymphocytes in some vertebrates.

The effect of hydrocortisone on functional activity of peripheral blood lymphocytes in different vertebrates during ontogeny was studied by the blast transformation test. Hydrocortisone in a dose of 100 mg/kg inhibited functional activities of T and B lymphocytes in vitro stimulated by mitogens. This inhibitory effect was observed in both young and adult animals.

[Effect of corticosteroid hormones on the lymphoid system of vertebrates].

Studies have been made on cellular mechanisms of changes in the lymphatic organs of some vertebrates after the effect of hydrocortisone. The latter in a dose 100 mg/kg of the body mass significantly decreases the activity of the thymus in the tortoise Testudo horsfieldi, albino mice and frogs. The decrease in lymphopoiesis was also observed in the spleen and bone marrow.