Dynamics of clinical and neurological changes in patients with acute ischemic stroke in an open clinical study.

Studies of treatment methods for patients with acute ischaemic stroke should include aetiological causes, concomitant pathology, and localisation of the lesion, and the extent of the lesion in the brain. The purpose of the study was to determine changes in clinical and neurological parameters in patients with ischaemic stroke in the acute period. This is an open clinical study for which 240 patients were selected with an acute condition after an ischaemic stroke.

A Note on the "One Case per Stagger Position" Character of Common Multiple-Baseline Intervention Designs.

Purpose: To overcome the constraint of common multiple-baseline designs that only one case per stagger position is permitted.

Methods: Three alternative strategies for assigning more than one case to each stagger position are examined.

Results: The three recommended strategies achieve the objective while maintaining the study's internal and statistical-conclusion validities.

Additional comparisons of randomization-test procedures for single-case multiple-baseline designs: Alternative effect types.

A number of randomization statistical procedures have been developed to analyze the results from single-case multiple-baseline intervention investigations. In a previous simulation study, comparisons of the various procedures revealed distinct differences among them in their ability to detect immediate abrupt intervention effects of moderate size, with some procedures (typically those with randomized intervention start points) exhibiting power that was both respectable and superior to other procedures (typically those with single fixed intervention start points). In Investigation 1 of the present follow-up simulation study, we found that when the same randomization-test procedures were applied to either delayed abrupt or immediate gradual intervention effects: (1) the powers of all of the procedures were severely diminished; and (2) in contrast to the previous study's results, the single fixed intervention start-point procedures generally outperformed those with randomized intervention start points.

Comparison of randomization-test procedures for single-case multiple-baseline designs.

In three simulation investigations, we examined the statistical properties of several different randomization-test procedures for analyzing the data from single-case multiple-baseline intervention studies. Two procedures (Wampold-Worsham and Revusky) are associated with single fixed intervention start points and three are associated with randomly determined intervention start points. Of the latter three, one (Koehler-Levin) is an existing procedure that has been previously examined and the other two (modified Revusky and restricted Marascuilo-Busk) are modifications and extensions of existing procedures.

[The results of the multicenter pharmaco-epidemiological observational project on the use of mydocalm in the treatment of pain syndromes with the muscle spasm].

The prospective multicenter open noncomparative pharmaco-epidemiological observational project on the use of mydocalm in real clinical practice has been completed in 2013. The project has been performed in 2090 clinical/rehabilitation settings in 284 cities of 13 countries using the results of 35,383 patients. The project aimed to assess the safety of treatment (percentage of patients with adverse-effects) and pain relieving efficacy as well as patient's satisfaction with the treatment.