Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome.

Introduction: Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes in brain structure. It is unknown if thickness and volumetric changes can identify AD stages and if they are similar to other genetic forms of AD.

Methods: Magnetic resonance imaging scans were collected for 178 DS adults (106 nonclinical, 45 preclinical, and 27 symptomatic).

Reduction in EEG theta power as a potential marker for spatial disorientation during flight.

During flight, spatial disorientation (SD) commonly occurs when a pilot's perception conflicts with the aircraft's actual motion, attitude, or position. A prevalent form of SD is the somatogyral illusion, which is elicited by constant speed rotation and causes a false perception of motion in the opposite direction when the rotation ceases. This research aimed to investigate changes in brain activity that occur when experiencing a somatogyral illusion by simulating conditions closely mimicking flight conditions to gain insight into how to better manage this illusion during flight.

Improved water, sanitation, hygiene and waste services in health-care facilities, Ukraine.

Problem: Water, sanitation and waste infrastructure and services in Ukrainian health-care facilities often fail to meet global and national standards, hindering the provision of safe, quality care. The war has worsened existing problems.

Approach: To incrementally improve water, sanitation, hand hygiene, environmental cleaning and health-care waste practices, the World Health Organization (WHO) is working with the health ministry, the Ukrainian Public Health Centre and regional United States Centers for Disease Prevention and Control (CDC) to implement the Water and Sanitation for Health Facility Improvement Tool (WASH FIT).

Utilization of Participatory Research Theory and a National Framework to Advance a State Food Security Research Agenda: A Mixed-Methods Study.

The 2022 White House National Strategy on Hunger, Nutrition, and Health outlined goals for ending hunger in the US. Actions fell into five areas, called pillars; the goal of Pillar 5 was to enhance nutrition and food security research. This study leveraged participatory research theory and the National Strategy for developing a statewide, evidence-informed food security research agenda.

Real-world safety and efficacy of teclistamab in relapsed/refractory multiple myeloma: results from a multicenter, retrospective study and descriptive meta-analysis.

Patients participating in clinical trials are highly selected and may not represent the general population. The pivotal study of teclistamab (MajesTEC-1), a B-cell maturation antigen (BCMA)xCD3 bispecific antibody, demonstrated impressive response rates and progression free survival in relapsed/refractory multiple myeloma (RRMM) with acceptable toxicity. We performed a retrospective study of 58 patients treated as standard of care at four US academic centers to determine how these results translated to the real-world.