Ribosome profiling and single-cell RNA sequencing identify the unfolded protein response as a key regulator of pigeon lactation.

Pigeons and certain other avian species produce a milk-like secretion in their crop sacs to nourish offspring, yet the detailed processes involved are not fully elucidated. This study investigated the crop sacs of 225-day-old unpaired non-lactating male pigeons (MN) and males initiating lactation on the first day after incubation (ML). Using RNA sequencing, ribosome profiling, and single-cell transcriptome sequencing (scRNA-seq), we identified a significant up-regulation of genes associated with ribosome assembly and protein synthesis in ML compared to MN.

Synthesis of shape-tunable PbZrTiO nanocrystals with lattice variations for piezoelectric energy harvesting and human motion detection.

PbZrTiO cubes with tunable sizes and cuboids have been hydrothermally synthesized. PbZrTiO cubes with three different Zr : Ti atomic percentages were also prepared. Analysis of synchrotron X-ray diffraction (XRD) patterns reveals the presence of two lattice components for these samples.

Ischemic colitis presenting as a colonic mass: a case report and diagnostic challenges.

Ischemic colitis (IC) is a multifaceted condition that often manifests with nonspecific symptoms such as abdominal pain and bloody diarrhea, particularly in older adults with vascular risk factors. Diagnosis is supported by elevated levels of white blood cells, lactate, and C-reactive protein (CRP). Computed tomography (CT) imaging typically reveals wall thickening and fat stranding in watershed areas.

Quantitative immunohistochemistry analysis of breast Ki67 based on artificial intelligence.

Breast cancer is a common malignant tumor of women. Ki67 is an important biomarker of cell proliferation. With the quantitative analysis, it is an important indicator of malignancy for breast cancer diagnosis.

Relationship between Internet use and offline leisure activities among Chinese older adult people: a moderated mediation model.

Background: The process of aging in Chinese society is accompanied by the concurrent development of the Internet. In recent years, the influence of Internet use on the activities of older adults has attracted growing interest and is now a significant focus of both public health and gerontological research. Nevertheless, there is a need for further empirical research in this area.