Publications by authors named "B S Bunney"
Resilience to Chronic Stress Is Characterized by Circadian Brain-Liver Coordination.
Biol Psychiatry Glob Open Sci
November 2024
Article Synopsis
- Chronic stress disrupts circadian rhythms, which can lead to mental and metabolic health issues; this study investigates how chronic social stress affects the circadian regulation of brain and liver functions in mice.
- Male mice underwent chronic social defeat stress, and their behaviors were analyzed to identify stress resilience and susceptibility, with tissue samples collected for further study every 4 hours.
- Findings suggest that resilient mice exhibit improved circadian transcription patterns and metabolic rhythms across different tissues, indicating better coordination between brain and liver functions compared to those susceptible to stress.
Transcription factors (TFs) regulate gene expression by facilitating or disrupting the formation of transcription initiation machinery at particular genomic loci. Because TF occupancy is driven in part by recognition of DNA sequence, genetic variation can influence TF-DNA associations and gene regulation. To identify variants that impact TF binding in human brain tissues, we assessed allele-specific binding (ASB) at heterozygous variants for 94 TFs in nine brain regions from two donors.
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- Transcription factors (TFs) are crucial for brain function and gene expression, but detailed binding information in human brain tissue is limited.
- Researchers created a comprehensive resource, called BrainTF, using multiple methods (like ChIP-seq and RNA-seq) to map the binding sites of over 100 TFs in various postmortem brain regions.
- The study found that certain neuronal TFs, such as SATB2 and TBR1, target unique regions important for gene expression and are linked to risk variants associated with neuropsychiatric disorders.
Transcription Factors (TFs) influence gene expression by facilitating or disrupting the formation of transcription initiation machinery at particular genomic loci. Because genomic localization of TFs is in part driven by TF recognition of DNA sequence, variation in TF binding sites can disrupt TF-DNA associations and affect gene regulation. To identify variants that impact TF binding in human brain tissues, we quantified allele bias for 93 TFs analyzed with ChIP-seq experiments of multiple structural brain regions from two donors.
View Article and Find Full Text PDFThe frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning prior to the age of onset for bipolar disorder (BP) and schizophrenia (SCHIZ), and its dysfunction is likely to underly aspects of their shared symptomology. In this study, we investigated the role of BA10 neurotransmission-related gene expression in BP and SCHIZ.
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