"How well do we know our patients?": Further validation of a complexity rating scale for HIV.

Background: Despite advances in the management and treatment of HIV, identifying risks for disengagement are essential to maximize positive outcomes. The current study investigated the validity of the Clinical Complexity Rating Scale for HIV (CCRS-HIV), a risk-prediction tool, by assessing agreement between patient and clinician scores of patient complexity.

Methods: 207 patients completed the patient version of the CCRS-HIV (CCRS-HIV), and six Attending Medical Officers (AMOs) caring for those individuals completed the original clinician version (CCRS-HIV).

Multiframe-based non-local means denoising for Raman spectra.

A method for denoising Raman spectra is presented in this paper. The approach is based on the principle that the original signal can be restored by averaging pixels based on structure similarity. Similarity searching and averaging are not limited to the neighbouring pixels but extended throughout the entire signal range across different frames.

Grating-incoupled waveguide-enhanced Raman sensor.

We report a waveguide-enhanced Raman spectroscopy (WERS) platform with alignment-tolerant under-chip grating input coupling. The demonstration is based on a 100-nm thick planar (slab) tantalum pentoxide (Ta2O5) waveguide and the use of benzyl alcohol (BnOH) and its deuterated form (d7- BnOH) as reference analytes. The use of grating couplers simplifies the WERS system by providing improved translational alignment tolerance, important for disposable chips, as well as contributing to improved Raman conversion efficiency.

Review of the Leaf Essential Oils of the Genus Sens. Lat. and a Report on the Leaf Essential Oils of and .

A review of the leaf oils of the 13 species now recognised in the genus is presented. This review carries on from, and incorporates data from, an earlier (1995) review of the then recognised eight species. The leaf oils of two new species of , and are reported for the first time.

Implementation of non-invasive prenatal testing within a national UK antenatal screening programme: Impact on women's choices.

Objective: To evaluate the implementation of non-invasive prenatal testing (NIPT) on pregnant women's choices in a national NHS antenatal screening programme for Down's syndrome, Edwards' syndrome and Patau's syndrome.

Method: An observational study of all pregnant women with a singleton pregnancy and higher chance (≤1:150) combined or quadruple screening result from 30 April 2018 to 25 September 2020 in Wales, UK. Pregnant women's journey through the pathway was determined including uptake of NIPT, performance of NIPT in a non-research setting and invasive procedures performed.