[Dynamics of ECG changes during the treatment of depressive conditions with different variants of the course of endogenous affective psychosis].

The ECG parameters were studied and compared in normal subjects and patients suffering from affective psychosis running bi- and monopolar course during the development of the depressive phase and after its removal. At the prodromal stage before treatment, the patients manifested sinus tachycardia, changes in the ST configuration and QRS complex. On the histograms of RR intervals distribution, the modal value was shifted to the area of short intervals, the mode amplitude was higher whereas the variation range was more narrow than in the healthy subjects.

[Clinical differentiation and classification of endogenous affective psychoses].

As many as 244 patients suffering from endogenous affective psychosis were examined by the clinico-catamnestic method. The clinical and pathogenetic heterogeneity of the given disease has been established. It manifests itself not only in the phenomenologic characteristics of the phasic affective conditions themselves but also in differences of the regularities of the disease course and prediction.

[Emotional reactivity of patients with depression].

Emotional reactivity of patients with endogenous depression and healthy test subjects towards classic and rock music was compared. According to the questionnaire data and EEG recording, it was established that in depressed patients, analysis and estimation of the emotionally significant information differ from those in healthy persons. In contrast to normals, the classic music exerts an activation effect on the patients whereas rock music evokes negative emotions.

[Clinico-pathopsychological study of personality traits and emotions in patients with affective psychoses].

During an experimental psychological examination of 75 patients with endogenous affective psychosis differentiated according to the affect polarity in the disease course, a study was made of the stable personality traits responsible for predisposition to the disease and characterizing the patients' emotional sphere. The comparison of the pathopsychological data to the clinical characteristics supported the rightfulness of differentiating the premanifest condition in accordance with the qualitative traits of the personality structure into pseudopsychopathic, psychopathic and accentuated states as most corresponding to the division of affective psychosis into the mono- and bipolar forms. The implication of the personality factors in the pathogenesis of the distinguished varieties of affective psychosis and the rightfulness of their differentiation by the polarity of the major affect in the disease picture are under discussion.

Does platelet serotonin receptor supersensitivity accompany endogenous depression?

In a population of drug-free bipolar and unipolar depressed women, it was found that the concentration of serotonin sufficient to induce half-maximal shape change velocity in platelets is significantly (p less than 0.001) lower (0.13 +/- 0.