Publications by authors named "B S Basavarajappa"
Article Synopsis
- - Cannabis sativa contains over 120 phytocannabinoids, with Δ-THC and CBD being the most recognized, but many lesser-known compounds are showing potential in affecting health through interactions with the endocannabinoid system.
- - These compounds can cross the blood-brain barrier and have antioxidant, anti-inflammatory, and neuro-modulatory properties that might help in treating neurodegenerative diseases.
- - While Δ-THC has been studied for its neuroprotective effects, there is increasing interest in non-psychotropic minor phytocannabinoids, which could offer therapeutic benefits for brain disorders and deserve more research.
Smart shoes have ushered in a new era of personalised health monitoring and assistive technologies. Smart shoes leverage technologies such as Bluetooth for data collection and wireless transmission, and incorporate features such as GPS tracking, obstacle detection, and fitness tracking. As the 2010s unfolded, the smart shoe landscape diversified and advanced rapidly, driven by sensor technology enhancements and smartphones' ubiquity.
View Article and Find Full Text PDFRecent genomics and epigenetic advances have empowered the exploration of DNA/RNA methylation and histone modifications crucial for gene expression in response to stress, aging and disease. Interest in understanding neuronal plasticity's epigenetic mechanisms, influencing brain rewiring amid development, aging and neurodegenerative disorders, continues to grow. Histone acetylation dysregulation, a commonality in diverse brain disorders, has become a therapeutic focus.
View Article and Find Full Text PDFDuring pregnancy, alcohol abuse and its detrimental effects on developing offspring are major public health, economic and social challenges. The prominent characteristic attributes of alcohol (ethanol) abuse during pregnancy in humans are neurobehavioral impairments in offspring due to damage to the central nervous system (CNS), causing structural and behavioral impairments that are together named fetal alcohol spectrum disorder (FASD). Development-specific alcohol exposure paradigms were established to recapitulate the human FASD phenotypes and establish the underlying mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- Synaptic plasticity refers to the brain's ability to strengthen or weaken synaptic connections, playing a crucial role in brain remodeling after various types of damage, including alcohol use disorders (AUDs).
- While significant research has focused on synaptic plasticity, its influence on neurobehavioral issues in AUDs, particularly in relation to fetal alcohol spectrum disorder (FASD), is still not fully understood.
- Recent studies suggest that prenatal alcohol exposure leads to synaptic and molecular changes that could serve as targets for new treatments to improve cognitive and behavioral outcomes in individuals affected by FASD.