Exploring Differences in the Lateralized Readiness Potential in Persons With Multiple Sclerosis Compared to Healthy Controls.

Multiple sclerosis (MS) is a neurodegenerative disease often leading to cognitive and motor impairment. Little research has examined motor preparation and initiation outcomes in the brain among persons with MS. The lateralized readiness potential is an ERP component that indexes pre-motor activity evaluating the stimulus (LRP-S) and motor activation for the response (LRP-R).

Evaluating transportability of overall survival estimates from US to UK populations receiving first-line treatment for advanced non-small cell lung cancer: a retrospective cohort study.

Objectives: The objective of this study is to explore how the UK versus the USA compare in patient characteristics, treatment patterns and overall survival (OS) of patients with advanced non-small cell lung cancer (aNSCLC) initiating first-line (1L) treatment.

Design: Retrospective cohort study.

Setting: Oncology treatment centres in the USA and UK.

Simultaneous detection of a wide range of synthetic and natural dyes in artworks using UHPLC-PDA-HRMS.

This paper presents a validated method using ultra-high pressure liquid chromatography with photodiode array detection coupled to high-resolution mass spectrometry (UHPLC-PDA-HRMS) for the simultaneous analysis of a wide range of natural and synthetic organic colourants, including neutral, acidic and basic dyes. In total, 30 natural and 62 synthetic organic dye reference samples (which contain 118 compounds because some of the dyes are composed of mixtures) were analysed. The method demonstrated good linearity for the 12 dyes selected for method validation achieving correlation coefficients (R) exceeding 0.

Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking.

Aggregates of stem cells can break symmetry and self-organize into embryo-like structures with complex morphologies and gene expression patterns. Mechanisms including reaction-diffusion Turing patterns and cell sorting have been proposed to explain symmetry breaking but distinguishing between these candidate mechanisms of self-organization requires identifying which early asymmetries evolve into subsequent tissue patterns and cell fates. Here we use synthetic 'signal-recording' gene circuits to trace the evolution of signalling patterns in gastruloids, three-dimensional stem cell aggregates that form an anterior-posterior axis and structures resembling the mammalian primitive streak and tailbud.