Cerebrospinal fluid CK enzyme and CK isoenzymes in the outcome prognosis of cerebrovascular disease.

The article presents the results of the analysis of total CK enzyme activity and CK isoenzymes in the cerebrospinal fluid of 148 patients with acute stroke, treated at the Intensive Care Unit of the Department of Neurology and Department of Neuropathology of the Clinical Hospital Center Rebro. The aim of the study was to determine the reliability of the applied methods in the prognosis of the outcome of cerebrovascular diseases. Greatly increased total CK enzyme activity is more frequently encountered in patients with ICH than in those with ISI.

Study of serum and cerebrospinal fluid enzymes in diagnosis and differential diagnosis of cerebrovascular diseases.

In the paper are presented the results of total enzyme activity investigation: GOT, GPT, LDH and CPK, and of the CPK isoenzymes in the cerebrospinal fluid of 148 examinees and in the serum of 67 examinees with an acute stroke, who were treated at the Intensive Care Unit of the Department of Neurology and Institute of Neuropathology, Clinical Medical center "Rebro". The aim was to determine the reliability of the applied methods in the diagnosis of cerebrovascular diseases, particularly in the differential diagnosis of cerebral hemorrhage, ischemia and subarachnoidal hemorrhage. The highest frequency of pathologic findings of the tested enzymes in the whole group of patients with CVA was obtained in the determination of the CPK total activity assessment, then followed the assessments of LDH activity, isoenzyme CPK profile, GOT and finally GPT activity.