Publications by authors named "B Rutgers"
Replication stress (RS) is a key trait of cancer cells, and a potential actionable target in cancer treatment. Accurate methods to measure RS in tumour samples are currently lacking. DNA fibre analysis has been used as a common technique to measure RS in cell lines.
View Article and Find Full Text PDFPlasmacytoma Variant Translocation 1 (PVT1) is a long non-coding RNA located at 8q24.21 immediately downstream of MYC. Both the linear and circular PVT1 transcripts contribute to cancer pathogenesis by binding microRNAs.
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- Increased Fab glycosylation of autoantibodies is prevalent in chronic B cell-mediated autoimmune diseases, with varying levels found across several conditions including rheumatoid arthritis and systemic lupus erythematosus.
- Assessment methods included lectin affinity chromatography and autoantigen-specific immunoassays to determine glycosylation levels.
- The study demonstrated that chronic disease states lead to increased Fab glycosylation, while acute autoimmune diseases did not show this association, suggesting a complex relationship between autoantigen exposure and glycosylation.
We previously described involvement of the MYC/miR-150/MYB/ZDHHC11 network in the growth of Burkitt lymphoma (BL) cells. Here we studied the relevance of this network in the two other B-cell lymphomas: Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL). Expression levels of the network components were assessed at the RNA and protein level.
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- MicroRNAs (miRNAs) play key roles in gene regulation for both normal and disease-related cellular processes, with a focus on Burkitt lymphoma (BL), a type of cancer driven by the MYC gene.
- A study using small RNA sequencing identified 26 miRNAs with significant expression differences between BL cell lines and normal germinal center B (GC-B) cells, confirming the role of five miRNAs in primary BL tissues.
- The study specifically highlighted miR-378a-3p as an oncogenic miRNA in BL, with its inhibition leading to reduced tumor growth and confirmed target genes, IRAK4 and MNT, which contribute to its growth-regulatory effects.