Publications by authors named "B Ruf"
Sensors (Basel)
October 2024
Article Synopsis
- * The technique uses a hierarchical approach, employing a plane-sweep algorithm combined with semi-global optimization to accurately create 3D models from large scenes typically seen in low-altitude drone images.
- * In tests, FaSS-MVS produces 3D data with high accuracy comparable to advanced offline methods like COLMAP, but does so much faster, processing images at 1-2 frames per second with significantly less computational time.
Article Synopsis
- Mammalian innate-like T cells (ILTCs), such as MAIT, NKT, and γδ T cells, play key roles in liver inflammation, tissue repair, and maintaining immune balance.
- The review discusses how different ILTC subsets contribute to liver diseases, focusing on their pro- and anti-inflammatory actions based on specific contexts.
- Recent findings emphasize the interactions between ILTCs and other immune cells, suggesting potential immunomodulatory strategies for better outcomes in liver disease treatment.
Article Synopsis
- Liver cancer is one of the most lethal cancers, and this study explores the role of the vagus nerve in tumor progression by regulating immune responses through acetylcholine (ACh).
- Liver denervation showed a significant reduction in liver tumors, while increasing parasympathetic activity led to tumor growth, indicating a complex relationship between cholinergic signals and adaptive immunity.
- The findings reveal that gut bacteria can affect both behavior and liver anti-tumor immunity through interactions with the vagus nerve, suggesting potential for new treatment targets.
Article Synopsis
- - This study introduces a new high-dimensional technique to analyze human γδ T cell subsets in their natural tissue settings, overcoming previous challenges related to antibody availability and technology limitations.
- - Researchers utilized a combination of multiplexed imaging and bioinformatics to identify and characterize γδ T cells in colon and colorectal cancer samples, uncovering various microenvironments and their interactions with both immune and cancer cells.
- - Although this initial study shows the promise of this advanced technology for exploring T cell diversity and microenvironments, further research is needed to connect specific T cell characteristics and microenvironment features with important clinical factors.
Article Synopsis
- The study investigates the limited effectiveness of immune checkpoint inhibitors (ICI) for liver cancer, specifically focusing on the role of adenosine signaling and A2a receptor (A2aR) inhibition combined with anti-PD1 therapy in mouse models.
- Researchers analyzed RNA expression related to the adenosine pathway, examined immune cells from liver cancer patients, and used various mouse models to test the combination therapy.
- Results showed that combining A2aR inhibition with anti-PD1 therapy can significantly enhance T cell activation and reduce tumor size in liver cancer models, suggesting this approach could improve treatment outcomes for patients.
