Increased Rate of Unique Mitochondrial DNA Deletion Breakpoints in Young Adults With Early-Life Stress.

Background: Mounting evidence suggests that mitochondria respond to psychosocial stress. Recent studies suggest mitochondrial DNA (mtDNA) deletions may be increased in some psychiatric disorders, but no studies have examined early-life stress (ELS) and mtDNA deletions. In this study, we assessed mtDNA deletions in peripheral blood mononuclear cells of medically healthy young adults with and without ELS.

Household Income Moderates Longitudinal Relations Between Neighborhood Child Opportunity Index and BMI Growth.

To examine longitudinal associations of early neighborhood Child Opportunity Index 2.0 (COI) with children's BMI trajectories and identify whether household economic resources moderate relations of COI in infancy/toddlerhood and the preschool years to longitudinal BMI growth between 2 and 12 years. Family data ( = 1091) were drawn from the Family Life Project, a longitudinal study of families residing in rural high-poverty areas.

Change in Child Opportunity Index in Early Childhood Is Associated with Youth BMI Growth.

The neighborhood-level child opportunity index (COI) has been used in policy-based initiatives to identify and improve low-resource neighborhoods in order to impact child health. Understanding of how changes in COI can impact child growth, however, is lacking. Participants were 1124 children from the Family Life Project, a longitudinal birth cohort of families in rural, high-poverty areas.