Publications by authors named "B Roca"
MicroRNAs (miRNAs) regulate approximately one-third of all human genes. The dysregulation of miRNAs has been implicated in the development of numerous human diseases, including cancers. In our investigation focusing on altering specific miRNA expression in human pancreatic cancer cells, we encountered an interesting finding.
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- This project is focused on creating eligibility criteria for menopausal hormone therapy (MHT), modeled after existing contraception guidelines.
- A consortium of scientific societies, led by the Spanish Menopause Society, conducted extensive research including 14 systematic reviews and 32 meta-analyses to assess MHT's safety across various health conditions.
- The results culminated in a structured eligibility framework categorizing MHT use from unrestricted to contraindicated, based on WHO standards and evaluated quality of evidence, aimed at aiding healthcare professionals in making informed decisions.
Introduction: Standard therapy for HIV treatment has consisted of two nucleoside analogue reverse transcriptase inhibitors (NRTI) paired with a third agent. Use of two-drug regimens (2DR) has been considered for selected patients in part to avoid toxicities associated with the use of NRTIs. This study aimed to compare the real-world outcomes of integrase inhibitor (INSTI)-based three-drug regimens (3DR) versus 2DR of dolutegravir (DTG) + rilpivirine (RPV) or DTG + lamivudine (3TC).
View Article and Find Full Text PDFBackground: knowledge of the present features of the HIV epidemic is relevant, especially to develop management programmes directed to poorly controlled patients.
Objectives: to describe the epidemiological and clinical features of HIV infection in a large multicentre cohort.
Design: cross-sectional study.
Introduction: Multi-pathological patients are at high risk of drug interactions and side effects. We aimed to assess the usefulness of 3 online drug interaction checkers.
Methods: In a cross-sectional study, carried out in the Medicine Department of Hospital General of Castellon, Spain, in February 2020, we assessed drug interaction detection with 3 online electronic checkers, Drugs.