Publications by authors named "B Rizzo"
Alzheimer's disease (AD) is a neurodegenerative disorder that progressively involves brain regions with an often-predictable pattern. Damage to the brain appears to spread and worsen with time, but the molecular mechanisms underlying the region-specific distribution of AD pathology at different stages of the disease are still under-investigated. In this study, a whole-transcriptome analysis was carried out on brain samples from the hippocampus (HI), temporal and parietal cortices (TC and PC, respectively), cingulate cortex (CG), and substantia nigra (SN) of six subjects with a definite AD diagnosis and three healthy age-matched controls in duplicate.
View Article and Find Full Text PDFAPOE ε4 allele is the major genetic risk factor for Alzheimer's Disease (AD). Furthermore, APOE methylation pattern has been described to be associated with the disease and to follow a bimodal pattern, with a hypermethylated CpG island and a hypomethylated promoter region. However, little is known about the methylation levels in the APOE 5'UTR region.
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- Accumulating senescent cells contribute to aging and diseases, prompting research into botanical extracts for potential therapies that could target these issues.
- A standardized extract of Salvia haenkei (HK) was found to extend both lifespan and healthspan in aged mice by reducing inflammation and markers of senescence while improving muscle strength and fur quality.
- The study identified luteolin, a flavonoid in HK, as a compound that disrupts the interaction between the proteins p16 and CDK6, suggesting a mechanism through which HK promotes longevity by modulating cellular senescence.
Article Synopsis
- * The relationship between oxidative stress and inflammation remains unclear—it's debated whether they cause neurodegenerative diseases or are effects of neuronal degeneration.
- * The review will spotlight amyotrophic lateral sclerosis (ALS) and evaluate how treatments using anti-inflammatory and antioxidant drugs have been tested, alongside a look at clinical trials and future research directions.
Article Synopsis
- Pufferfish in the Mediterranean Sea are potentially dangerous due to the accumulation of toxic substances like tetrodotoxin (TTXs) and saxitoxin (STXs) in their tissues, posing a public health risk.
- A study conducted in the Strait of Sicily involved local fishermen collecting pufferfish samples, which were then analyzed for toxins using advanced testing methods.
- Findings showed that all examined tissues were negative for TTXs and STXs, highlighting the importance of citizen science in monitoring marine species and assessing public health risks associated with these fish.