Publications by authors named "B Rintelen"
Article Synopsis
- The study aimed to create machine learning models to predict the effectiveness of five different biological disease-modifying antirheumatic drugs (bDMARDs) using patient data from the Austrian Biologics Registry.
- A total of 1397 patients' data with 19 variables was analyzed, leading to the development of models that can predict the risk of ineffectiveness of these drugs within the first 26 weeks of treatment.
- Results showed varied prediction accuracy for each drug, highlighting the importance of specific patient factors, such as dosage and co-therapy, suggesting that machine learning can aid in tailored drug selection for patients.
Objective: The SF-SACRAH was developed to assess the involvement of the hand in rheumatoid arthritis (RA) and hand osteoarthritis (HOA) patients in daily clinical routines. In this pilot study, its sensitivity to change will be assessed longitudinally, and preliminary thresholds for patient relevant changes are derived.
Methods: Ninety-nine outpatients suffering from HOA ( = 55) or RA ( = 44) completed the SF-SACRAH once initially.
Treating to target by monitoring disease activity and adjusting therapy to attain remission or low disease activity has been shown to lead to improved outcomes in chronic rheumatic diseases such as rheumatoid arthritis and spondyloarthritis. Patient-reported outcomes, used in conjunction with clinical measures, add an important perspective of disease activity as perceived by the patient. Several validated PROs are available for inflammatory arthritis, and advances in electronic patient monitoring tools are helping patients with chronic diseases to self-monitor and assess their symptoms and health.
View Article and Find Full Text PDFTighter monitoring of patients is regarded one of the key approaches to improve management of rheumatoid arthritis (RA). It could be demonstrated that the patient relevant disease course is not simply the linear link between two observation points, but fluctuates significantly in up to 80% of patients surveyed three times over two months, which understandably compromises quality of life. Patient self-report questionnaires such as the Rheumatoid Arthritis Disease Activity Index-Five (RADAI-5) have been shown to provide reliable information about disease activity, functionality, and other important aspects of daily life.
View Article and Find Full Text PDF