Publications by authors named "B Reiter"
Introduction: Hemodialysis patients (HDPs) exhibit extensive cardiovascular risk. The widely prescribed anti-platelet agent clopidogrel is metabolically activated by cytochrome enzymes, which may be impaired by uremia and chronic low-grade inflammation, typically present in HDPs. We conducted a prospective multicenter study to investigate the pharmacokinetics and pharmacodynamics of clopidogrel in HDPs and healthy volunteers (HVs).
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- Clomipramine (CLOMI) is effective for premature ejaculation but may cause erectile dysfunction, while yohimbine (YOH) helps with erectile dysfunction and could boost libido; combining both drugs may harness their benefits.
- In a study with 15 healthy male subjects, researchers analyzed how these drugs interact when taken together, assessing their pharmacokinetics and safety profiles through various plasma sampling methods.
- Results indicated a significant interaction with YOH when combined with CLOMI, suggesting competitive inhibition of YOH metabolism by CLOMI, but this interaction is considered minor according to regulatory guidelines, which supports further studies on their combined efficacy.
Background: Obesity in pregnancy is linked to adverse clinical outcomes such as gestational diabetes. Recently, a risk score calculated by different ceramide concentrations was recognized as a new way to investigate cardiovascular risk. The aim was to analyze if the ceramide risk score and cardiometabolic risk vary between normal-weight, obese, and females with prior Roux-en-Y bypass surgery (RYGB) during pregnancy.
View Article and Find Full Text PDFIntroduction: Macrophage dysfunction is a common feature of inflammatory disorders such as asthma, which is characterized by a strong circadian rhythm.
Methods And Results: We monitored the protein expression pattern of the molecular circadian clock in human peripheral blood monocytes from healthy, allergic, and asthmatic donors during a whole day. Monocytes cultured of these donors allowed us to examine circadian protein expression in human monocyte-derived macrophages, M1- and M2- polarized macrophages.
Background: Deep sternal wound infection (DSWI) remains a serious complication after coronary artery bypass grafting (CABG). We herein aimed to stratify diabetic patients who underwent CABG using bilateral internal mammary artery (BIMA) for levels of glycated hemoglobin A1C (HbA1c) and compare postoperative outcomes.
Methods: Between January 2010 and August 2020, 4,186 consecutive patients underwent isolated CABG at our center.