Publications by authors named "B Rathkolb"
Article Synopsis
- The lncRNA Crossfirre is an X-linked gene that is transcribed opposite to another lncRNA called Firre, and together with Dxz4, they form significant chromatin structures specific to inactive X chromosomes.
- Researchers carried out large-scale knockout studies of Crossfirre, Firre, and Dxz4 to understand their in vivo roles, finding that although these loci have unique epigenetic traits, they are not crucial for X chromosome inactivation processes.
- The study reveals that Crossfirre influences the regulation of autosomal genes, but only in conjunction with Firre, and includes a phenotyping analysis that highlights various knockout and sex-specific outcomes.
Exposure to nanoparticles (NPs) is frequently associated with adverse cardiovascular effects. In contrast, NPs in nanomedicine hold great promise for precise lung-specific drug delivery, especially considering the extensive pulmonary capillary network that facilitates interactions with bloodstream-suspended particles. Therefore, exact knowledge about effects of engineered NPs within the pulmonary microcirculation are instrumental for future application of this technology in patients.
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- Scientists are studying how to help the body make more insulin-producing β-cells to manage diabetes better.
- They used zebrafish to see if liver cells (hepatocytes) can help regenerate these β-cells but found they don’t turn into β-cells themselves.
- A special process involving something called molybdenum cofactor may be important for both making β-cells and managing sugar levels in the body, which could help in understanding diabetes better.
Purpose: Growth hormone (GH) is a central regulator of β-cell proliferation, insulin secretion and sensitivity. Aim of this study was to investigate the effect of GH insensitivity on pancreatic β-cell histomorphology and consequences for metabolism in vivo.
Methods: Pancreata from pigs with growth hormone receptor deficiency (GHR-KO, n = 12) were analyzed by unbiased quantitative stereology in comparison to wild-type controls (WT, n = 12) at 3 and 7-8.
Thyroid hormone (TH) effects are mediated through TH receptors (TRs), TRα1, TRβ1, and TRβ2. The TRs bind to the DNA and regulate expression of TH target genes (canonical signaling). In addition, they mediate activation of signaling pathways (noncanonical signaling).
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